1142050-84-7
Chemical Structure
LP-403812
- CAS No.: 1142050-84-7
- Formula:C26H34N6O2S
- Molecular Weight:494.65
IUPAC Name: (S)-N-(1-(tert-butyl)-3-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrazolo[3,4-d]thiazol-5-yl)-4-methylbenzamide
InChIKey: GJBQMIZKUFMWPV-IBGZPJMESA-N
SMILES: O=C(NC1=NC(N(C(C)(C)C)N=C2C(N3[C@H](CN4CCCC4)CCC3)=O)=C2S1)C5=CC=C(C)C=C5
Biological Activity: LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC50=0.11 μM; Ki=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC50=0.23 μM). LP-403812 can be used to study the function of PROT in the brain[1].
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LP-403812 | LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC50=0.11 μM; Ki=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC50=0.23 μM). LP-403812 can be used to study the function of PROT in the brain. | |||||||||||||||||||||
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Keywords
