115904-74-0
Chemical Structure
DuP 747 hydrochloride
- CAS No.: 115904-74-0
- Formula:C24H29Cl3N2O2
- Molecular Weight:483.86
InChIKey: FPNBFLNBNPFFFA-TUYUPMGOSA-N
SMILES: ClC(C=C1CC(N([C@H]2C3=CC=CC(OC)=C3CC[C@@H]2N4CCCC4)C)=O)=C(C=C1)Cl.Cl
Biological Activity: DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration[1].
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DuP 747 hydrochloride | DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration. | |||||||||||||||||||||
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