124875-20-3
124875-20-3
Chemical Structure
KP1019
Synonym(s): FFC14A
- CAS No.: 124875-20-3
- Formula:C21H19Cl4N6Ru
- Molecular Weight:598.30
InChIKey: PJXASRBEMZORRI-UHFFFAOYSA-K
SMILES: [Cl-][Ru+3]([Cl-])([Cl-])([N]1=CC2=C(N1)C=CC=C2)([N]3=CC4=C(N3)C=CC=C4)[Cl-].C5(C=NN6)=C6C=CC=C5.[H+]
Biological Activity: KP1019 (FFC14A) is a Ru(III)-based anti-metastatic and cytotoxic anti-cancer agent. KP1019 induces DNA damage and apoptosis in cancer cells[1][2].
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KP1019 | KP1019 (FFC14A) is a Ru(III)-based anti-metastatic and cytotoxic anti-cancer agent. KP1019 induces DNA damage and apoptosis in cancer cells. | |||||||||||||||||||||
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References
- [1]. Shannon K Stevens, et al. The anticancer ruthenium complex KP1019 induces DNA damage, leading to cell cycle delay and cell death in Saccharomyces cerevisiae. Mol Pharmacol. 2013 Jan;83(1):225-34. [Content Brief]
- [2]. Gemma K Gransbury, et al. Comparison of KP1019 and NAMI-A in tumour-mimetic environments. Metallomics. 2016 Aug 1;8(8):762-73. [Content Brief]
Keywords
