127182-67-6
Chemical Structure
Cefetecol hydrate
Synonym(s): GR69153 hydrate
- CAS No.: 127182-67-6
- Formula:C20H25N5O13S2
- Molecular Weight:607.57
IUPAC Name: (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((S)-carboxy(3,4-dihydroxyphenyl)methoxy)imino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
InChIKey: HYKRFONDLKBUTH-XKULUCSCSA-N
SMILES: O=C1N2[C@@](SCC=C2C(O)=O)([H])[C@@H]1NC(/C(C3=CSC(N)=N3)=N\O[C@@H](C4=CC(O)=C(C=C4)O)C(O)=O)=O.O.O.O.O
Biological Activity: Cefetecol hydrate (GR69153 hydrate) is a semisynthetic β-lactam antibacterial agent and α-glucosidase inhibitor (yeast IC50 = 2.1 μM; Ki = 5.78 μM) that crosses the blood-brain barrier. Cefetecol hydrate reduces blood glucose levels in Streptozotocin-induced diabetic mice. Cefetecol hydrate decreases the mRNA expression of GSK-3, PPAR-γ, and UCP-3. Cefetecol hydrate induces bacterial cell filamentation and exhibits bactericidal activity against Gram-positive and Gram-negative bacteria. Cefetecol hydrate is used in the study of diabetes and bacterial infections[1][2][3].
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Cefetecol hydrate | Cefetecol hydrate (GR69153 hydrate) is a semisynthetic β-lactam antibacterial agent and α-glucosidase inhibitor (yeast IC50 = 2.1 μM; Ki = 5.78 μM) that crosses the blood-brain barrier. Cefetecol hydrate reduces blood glucose levels in Streptozotocin-induced diabetic mice. Cefetecol hydrate decreases the mRNA expression of GSK-3, PPAR-γ, and UCP-3. Cefetecol hydrate induces bacterial cell filamentation and exhibits bactericidal activity against Gram-positive and Gram-negative bacteria. Cefetecol hydrate is used in the study of diabetes and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Lee DS, et al. Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. International journal of molecular medicine. 2007 Sep;20(3):379-83. [Content Brief]
- [2]. Harada Y, et al. Ceftezole, a new cephalosporin C derivative II. Distribution and excretion in parenteral administration. J Antibiot (Tokyo). 1976 Oct;29(10):1071-82. [Content Brief]
- [3]. Noto T, et al. Ceftezole, a new cephalosporin C derivative I. In vitro and in vivo antimicrobial activity. The Journal of antibiotics. 1976 Oct;29(10):1058-70. [Content Brief]
