141774-20-1
141774-20-1
Chemical Structure
NPC-15437 dihydrochloride
- CAS No.: 141774-20-1
- Formula:C25H52Cl2N4O2
- Molecular Weight:511.61
IUPAC Name: (2S)-2,6-diamino-N-((1-tridecanoylpiperidin-2-yl)methyl)hexanamide dihydrochloride
InChIKey: RISSBZWRJRRXTD-OLBPYZPGSA-N
SMILES: NCCCC[C@H](N)C(NCC1N(CCCC1)C(CCCCCCCCCCCC)=O)=O.Cl.Cl
Biological Activity: NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NPC-15437 dihydrochloride | 98.66% | NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation. | ||||||||||||||||||||
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References
- [1]. Mathis C, et al. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol. 1992 Sep 10;220(1):107-10. [Content Brief]
- [2]. Sullivan JP, et al. 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Maheux, J., et al. Pharmacol. 1992 Jan;41(1):38-44. [Content Brief]
- [3]. Modulation of Nur77 expression by dopaminergic drug is altered by a MEK pathway inhibitor in vivo. The FASEB Journal, 20: A684-A685.
