NPC-15437 dihydrochloride

Cat. No.: HY-129980 Purity: 98.66%: Data Sheet
COA

SDS
Handling Instructions
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NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC₅₀ of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation.

For research use only. We do not sell to patients.

NPC-15437 dihydrochloride Chemical Structure

CAS No. : 141774-20-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Other Forms of NPC-15437 dihydrochloride:

NPC-15437 Get quote

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•Related Screening Libraries:

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•Related Proteins:

View All PKC Isoform Specific Products:

View All Isoforms

PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

511.61

Formula

C₂₅H₅₂Cl₂N₄O₂

CAS No.

141774-20-1

Appearance

Solid

Color

White to off-white

SMILES

NCCCC[C@H](N)C(NCC1N(CCCC1)C(CCCCCCCCCCCC)=O)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (97.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9546 mL	9.7731 mL	19.5461 mL
5 mM	0.3909 mL	1.9546 mL	3.9092 mL
10 mM	0.1955 mL	0.9773 mL	1.9546 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.66%

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Data Sheet (266 KB) SDS (251 KB)

COA (241 KB) HNMR (289 KB) LCMS (334 KB)

Handling Instructions (2659 KB)

References

[1]. Mathis C, et al. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol. 1992 Sep 10;220(1):107-10. [Content Brief]

[2]. Sullivan JP, et al. 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Maheux, J., et al. Pharmacol. 1992 Jan;41(1):38-44. [Content Brief]

[3]. Modulation of Nur77 expression by dopaminergic drug is altered by a MEK pathway inhibitor in vivo. The FASEB Journal, 20: A684-A685.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9546 mL	9.7731 mL	19.5461 mL	48.8653 mL
	5 mM	0.3909 mL	1.9546 mL	3.9092 mL	9.7731 mL
	10 mM	0.1955 mL	0.9773 mL	1.9546 mL	4.8865 mL
	15 mM	0.1303 mL	0.6515 mL	1.3031 mL	3.2577 mL
	20 mM	0.0977 mL	0.4887 mL	0.9773 mL	2.4433 mL
	25 mM	0.0782 mL	0.3909 mL	0.7818 mL	1.9546 mL
	30 mM	0.0652 mL	0.3258 mL	0.6515 mL	1.6288 mL
	40 mM	0.0489 mL	0.2443 mL	0.4887 mL	1.2216 mL
	50 mM	0.0391 mL	0.1955 mL	0.3909 mL	0.9773 mL
	60 mM	0.0326 mL	0.1629 mL	0.3258 mL	0.8144 mL
	80 mM	0.0244 mL	0.1222 mL	0.2443 mL	0.6108 mL