NPC-15437 dihydrochloride
Based on 1 Customer Validation
NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation.
For research use only. We do not sell to patients.
- Purity: 98.66%
- CAS No.: 141774-20-1
- Formula: C25H52Cl2N4O2
- Molecular Weight:511.61
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 141774-20-1
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Appearance Solid
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Molecular Weight 511.61
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Formula C25H52Cl2N4O2
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Color White to off-white
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SMILES
NCCCC[C@H](N)C(NCC1N(CCCC1)C(CCCCCCCCCCCC)=O)=O.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (97.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Mathis C, et al. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol. 1992 Sep 10;220(1):107-10. [Content Brief]
[2]. Sullivan JP, et al. 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Maheux, J., et al. Pharmacol. 1992 Jan;41(1):38-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9546 mL | 9.7731 mL | 19.5461 mL | 48.8653 mL |
| 5 mM | 0.3909 mL | 1.9546 mL | 3.9092 mL | 9.7731 mL | |
| 10 mM | 0.1955 mL | 0.9773 mL | 1.9546 mL | 4.8865 mL | |
| 15 mM | 0.1303 mL | 0.6515 mL | 1.3031 mL | 3.2577 mL | |
| 20 mM | 0.0977 mL | 0.4887 mL | 0.9773 mL | 2.4433 mL | |
| 25 mM | 0.0782 mL | 0.3909 mL | 0.7818 mL | 1.9546 mL | |
| 30 mM | 0.0652 mL | 0.3258 mL | 0.6515 mL | 1.6288 mL | |
| 40 mM | 0.0489 mL | 0.2443 mL | 0.4887 mL | 1.2216 mL | |
| 50 mM | 0.0391 mL | 0.1955 mL | 0.3909 mL | 0.9773 mL | |
| 60 mM | 0.0326 mL | 0.1629 mL | 0.3258 mL | 0.8144 mL | |
| 80 mM | 0.0244 mL | 0.1222 mL | 0.2443 mL | 0.6108 mL |
NPC-15437 dihydrochloride Related Classifications
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