1-Oleoyl-2-acetyl-sn-glycerol
Based on 2 publication(s) in Google Scholar
1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of diacylglycerol (DAG) and can activate Protein kinase C (PKC). 1-Oleoyl-2-acetyl-sn-glycerol can activate the TRPC channels-mediated specific Ca2+ influx. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate superoxide-generation from human neutrophils. 1-Oleoyl-2-acetyl-sn-glycerol stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate ascites tumor cell proliferation.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 86390-77-4
- Formula: C23H42O5
- Molecular Weight:398.58
-
Storage:
Solution, -20°C, protect from light, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
HY-13453
BAY 11-7082 -
HY-15699
SAR7334 -
HY-131897
1-Stearoyl-2-arachidonoyl-sn-glycerol -
HY-13689
Go 6983 -
HY-W010736
(S)-3-Hydroxypropane-1,2-diyl dipalmitate -
HY-P0154
Epsilon-V1-2 -
HY-10195B
Ruboxistaurin hydrochloride -
HY-10230
Midostaurin -
HY-129624A
Bisindolylmaleimide VIII acetate -
HY-W010736R
1,2-Dipalmitoyl-sn-glycerol (Standard) -
HY-W587552
1,3-Diolein -
HY-108136A
Bisindolylmaleimide X hydrochloride
Publications Citing Use of MedChemExpress (MCE) 1-Oleoyl-2-acetyl-sn-glycerol
More
Biological Activity
Description
In Vitro
1-Oleoyl-2-acetyl-sn-glycerol (0-400 μM) induce the O2- release in neutrophils[1].
1-Oleoyl-2-acetyl-sn-glycerol (30-100 μM) can directly activate the endogenous TRPC3, TRPC6, and TRPC7 channels expressed in HEK 293 cells, inducing intracellular Ca2+ influx without stimulating the activity of adenylate cyclase 8[2].
1-Oleoyl-2-acetyl-sn-glycerol induces a concomitant increase in [32P]-incorporation in phosphatidylinositol 4-phosphate (PIP) and in the 40K protein, the endogenous substrate for protein kinase C in human platelets[3].
1-Oleoyl-2-acetyl-sn-glycerol reduces inositol phosphates levels in ascites cells, such as IP3[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 86390-77-4
-
Appearance Liquid
-
Molecular Weight 398.58
-
Formula C23H42O5
-
Color Colorless to light yellow
-
SMILES
OC[C@H](OC(C)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Solution, -20°C, protect from light, 2 years
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Mol Biol Rep
Astragaloside IV inhibits palmitic acid-induced apoptosis through regulation of calcium homeostasis in mice podocytes. [Abstract]2021 Feb;48(2):1453-1464. PMID: 33606151 -
Purity & Documentation
-
Data Sheet (266 KB)
-
SDS (587 KB)
- English - EN (587 KB)
- Français - FR (587 KB)
- Deutsch - DE (587 KB)
- Norwegian - NO (587 KB)
- Español - ES (587 KB)
- Swedish - SV (587 KB)
- Italian - IT (587 KB)
- Korean - KR (587 KB)
- Portuguese - PT (587 KB)
-
Handling Instructions (2659 KB)
References
[1]. Fujita I, Irita K, Takeshige K, Minakami S. Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils. Biochem Biophys Res Commun. 1984;120(2):318-324. [Content Brief]
[2]. Martin AC, Cooper DM. Capacitative and 1-oleyl-2-acetyl-sn-glycerol-activated Ca(2+) entry distinguished using adenylyl cyclase type 8. Mol Pharmacol. 2006;70(2):769-777. [Content Brief]
[3]. de Chaffoy de Courcelles D, et al. 1-Oleoyl-2-acetyl-glycerol (OAG) stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. Biochem Biophys Res Commun. 1984 Sep 17;123(2):589-95. [Content Brief]
[4]. Strosznajder JB, et al. Effect of 1-oleoyl-2-acetyl-sn-glycerol on inositol lipid metabolism of ascites tumor cells in culture. J Lipid Mediat. 1989 May-Jun;1(3):175-87. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-Oleoyl-2-acetyl-sn-glycerol Related Classifications
HY-131648 Related Classifications
Powered by Bioz