1-Oleoyl-2-acetyl-sn-glycerol

Cat. No.: HY-131648 Pureté: 99.9%: Fiche technique
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1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of diacylglycerol (DAG) and can activate Protein kinase C (PKC). 1-Oleoyl-2-acetyl-sn-glycerol can activate the TRPC channels-mediated specific Ca²⁺ influx. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate superoxide-generation from human neutrophils. 1-Oleoyl-2-acetyl-sn-glycerol stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate ascites tumor cell proliferation.

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1-Oleoyl-2-acetyl-sn-glycerol Chemical Structure

CAS No. : 86390-77-4

Size	Stock	Quantité
Solvent
5 mg (25.09 mM * 500 μL in Acetonitrile)	En stock	Estimated Time of Arrival: December 31
Solvent
10 mg (25.09 mM * 1 mL in Acetonitrile)	En stock	Estimated Time of Arrival: December 31
Solvent
25 mg (25.09 mM * 2.5 mL in Acetonitrile)	En stock	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE 1-Oleoyl-2-acetyl-sn-glycerol

•Mol Biol Rep. 2021 Feb;48(2):1453-1464. [Abstract]

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•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform PKC:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

Voir tous les produits spécifiques à Isoform TRP Channel:

Voir toutes les isoformes

TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

Activité biologique
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Description	1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of diacylglycerol (DAG) and can activate Protein kinase C (PKC). 1-Oleoyl-2-acetyl-sn-glycerol can activate the TRPC channels-mediated specific Ca²⁺ influx. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate superoxide-generation from human neutrophils. 1-Oleoyl-2-acetyl-sn-glycerol stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate ascites tumor cell proliferation^[1]^[2]^[3]^[4].
In Vitro	1-Oleoyl-2-acetyl-sn-glycerol (0-400 μM) induce the O₂^- release in neutrophils^[1]. 1-Oleoyl-2-acetyl-sn-glycerol (30-100 μM) can directly activate the endogenous TRPC3, TRPC6, and TRPC7 channels expressed in HEK 293 cells, inducing intracellular Ca²⁺ influx without stimulating the activity of adenylate cyclase 8^[2]. 1-Oleoyl-2-acetyl-sn-glycerol induces a concomitant increase in [32P]-incorporation in phosphatidylinositol 4-phosphate (PIP) and in the 40K protein, the endogenous substrate for protein kinase C in human platelets^[3]. 1-Oleoyl-2-acetyl-sn-glycerol reduces inositol phosphates levels in ascites cells, such as IP3^[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 1-Oleoyl-2-acetyl-sn-glycerol Related Antibodies
Masse moléculaire	398.58
Formule	C₂₃H₄₂O₅
CAS No.	86390-77-4
Appearance	Liquid
Color	Colorless to light yellow
SMILES	OC[C@H](OC(C)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
Livraison	Room temperature in continental US; may vary elsewhere.
Stockage	Solution, -20°C, protect from light, 2 years
Pureté et documentation	Purity: 99.90% Select Batch: Fiche technique (266 KB) SDS (585 KB) COA (238 KB) Elemental Analysis Report (97 KB) Instruction de manipulation (2659 KB)
Références	[1]. Fujita I, Irita K, Takeshige K, Minakami S. Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils. Biochem Biophys Res Commun. 1984;120(2):318-324. [Content Brief] [2]. Martin AC, Cooper DM. Capacitative and 1-oleyl-2-acetyl-sn-glycerol-activated Ca(2+) entry distinguished using adenylyl cyclase type 8. Mol Pharmacol. 2006;70(2):769-777. [Content Brief] [3]. de Chaffoy de Courcelles D, et al. 1-Oleoyl-2-acetyl-glycerol (OAG) stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. Biochem Biophys Res Commun. 1984 Sep 17;123(2):589-95. [Content Brief] [4]. Strosznajder JB, et al. Effect of 1-oleoyl-2-acetyl-sn-glycerol on inositol lipid metabolism of ascites tumor cells in culture. J Lipid Mediat. 1989 May-Jun;1(3):175-87. [Content Brief]