1. Epigenetics
    TGF-beta/Smad
    Cell Cycle/DNA Damage
  2. PKC
    CDK
  3. Bisindolylmaleimide X hydrochloride

Bisindolylmaleimide X hydrochloride (Synonyms: BIM-X hydrochloride; Ro31-8425 hydrochloride)

Cat. No.: HY-108136A Purity: 98.53%
Handling Instructions

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM.

For research use only. We do not sell to patients.

Bisindolylmaleimide X hydrochloride Chemical Structure

Bisindolylmaleimide X hydrochloride Chemical Structure

CAS No. : 145317-11-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 160 In-stock
Estimated Time of Arrival: December 31
5 mg USD 145 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM[1].

IC50 & Target[1]

PKC

 

CDK2

200 nM (IC50)

Molecular Weight

460.96

Formula

C₂₆H₂₅ClN₄O₂

CAS No.

145317-11-9

SMILES

O=C(C(C1=C(CC(CN)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (45.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1694 mL 10.8469 mL 21.6939 mL
5 mM 0.4339 mL 2.1694 mL 4.3388 mL
10 mM 0.2169 mL 1.0847 mL 2.1694 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Bisindolylmaleimide X hydrochloride
Cat. No.:
HY-108136A
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