86390-77-4
Chemical Structure
1-Oleoyl-2-acetyl-sn-glycerol
- CAS No.: 86390-77-4
- Formula:C23H42O5
- Molecular Weight:398.58
IUPAC Name: (S)-2-acetoxy-3-hydroxypropyl oleate
InChIKey: PWTCCMJTPHCGMS-YRBAHSOBSA-N
SMILES: OC[C@H](OC(C)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
Biological Activity: 1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of diacylglycerol (DAG) and can activate Protein kinase C (PKC). 1-Oleoyl-2-acetyl-sn-glycerol can activate the TRPC channels-mediated specific Ca2+ influx. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate superoxide-generation from human neutrophils. 1-Oleoyl-2-acetyl-sn-glycerol stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate ascites tumor cell proliferation[1][2][3][4].
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1-Oleoyl-2-acetyl-sn-glycerol | 99.90% | 1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of diacylglycerol (DAG) and can activate Protein kinase C (PKC). 1-Oleoyl-2-acetyl-sn-glycerol can activate the TRPC channels-mediated specific Ca2+ influx. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate superoxide-generation from human neutrophils. 1-Oleoyl-2-acetyl-sn-glycerol stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate ascites tumor cell proliferation. | ||||||||||||||||||||
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- [1]. Fujita I, Irita K, Takeshige K, Minakami S. Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils. Biochem Biophys Res Commun. 1984;120(2):318-324. [Content Brief]
- [2]. Martin AC, Cooper DM. Capacitative and 1-oleyl-2-acetyl-sn-glycerol-activated Ca(2+) entry distinguished using adenylyl cyclase type 8. Mol Pharmacol. 2006;70(2):769-777. [Content Brief]
- [3]. de Chaffoy de Courcelles D, et al. 1-Oleoyl-2-acetyl-glycerol (OAG) stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. Biochem Biophys Res Commun. 1984 Sep 17;123(2):589-95. [Content Brief]
- [4]. Strosznajder JB, et al. Effect of 1-oleoyl-2-acetyl-sn-glycerol on inositol lipid metabolism of ascites tumor cells in culture. J Lipid Mediat. 1989 May-Jun;1(3):175-87. [Content Brief]
Keywords
