1431628-22-6
1431628-22-6
Chemical Structure
(S)-UFR2709
- CAS No.: 1431628-22-6
- Formula:C13H17NO2
- Molecular Weight:219.28
IUPAC Name: (S)-(1-methylpyrrolidin-2-yl)methyl benzoate
InChIKey: PXVQMUATEFMGFD-LBPRGKRZSA-N
SMILES: O=C(C1=CC=CC=C1)OC[C@H](CCC2)N2C
Biological Activity: (S)-UFR2709 is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2].
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(S)-UFR2709 | (S)-UFR2709 is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction. | |||||||||||||||||||||
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References
- [1]. Gabriel Quiroz, et al. UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. Front Pharmacol. 2019 Dec 3;10:1429. [Content Brief]
- [2]. Franco Viscarra, et al. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish. Molecules. 2020 Jun 30;25(13):2998. [Content Brief]
