143782-20-1
143782-20-1
Chemical Structure
RU 56279
- CAS No.: 143782-20-1
- Formula:C13H10F3N3O2
- Molecular Weight:297.23
IUPAC Name: 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
InChIKey: CYCKLVAQENOQPG-UHFFFAOYSA-N
SMILES: CC(C1=O)(C)NC(N1C2=CC(C(F)(F)F)=C(C#N)C=C2)=O
Biological Activity: RU 56279 is an androgen receptor (AR) antagonist with strong and systemic anti-androgenic activity. RU 56279 is also a common, potent and long-lasting anti-androgen metabolite of RU 56187 (HY-117486) and RU 58841 (HY-10561) in vivo. RU 56279 can be used as an AR ligand to construct an AR-targeted prodrug system for the study of AR-positive tumor cells[1][2].
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RU 56279 | RU 56279 is an androgen receptor (AR) antagonist with strong and systemic anti-androgenic activity. RU 56279 is also a common, potent and long-lasting anti-androgen metabolite of RU 56187 (HY-117486) and RU 58841 (HY-10561) in vivo. RU 56279 can be used as an AR ligand to construct an AR-targeted prodrug system for the study of AR-positive tumor cells. | |||||||||||||||||||||
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References
- [1]. Cousty-Berlin D, et al. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite. J Steroid Biochem Mol Biol. 1994 Oct;51(1-2):47-55. [Content Brief]
- [2]. Cogan PS, Koch TH. Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. J Med Chem. 2003 Nov 20;46(24):5258-70. [Content Brief]
