155319-91-8
155319-91-8
Chemical Structure
Mangafodipir
- CAS No.: 155319-91-8
- Formula:C22H30MnN4O14P2
- Molecular Weight:691.38
InChIKey: QDQFSBKXQQZVTB-UHFFFAOYSA-L
SMILES: O=C1[O-][Mn+2]([N]2(C3)CC4=C5COP([O-])([O-])=O)([O-]C6=C(N=C7)C)([O-]C4=C(N=C5)C)([O-]C3=O)[N](CC6=C7COP([O-])([O-])=O)(CC2)C1.[H+].[H+].[H+].[H+].[H+].[H+]
Biological Activity: Mangafodipir, hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir shows no negative interference with the tumoricidal activity of chemotherapy[1][2].
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Mangafodipir | Mangafodipir, hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir shows no negative interference with the tumoricidal activity of chemotherapy. | |||||||||||||||||||||
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References
- [1]. Karlsson JOG, et al. Mangafodipir a Selective Cytoprotectant - with Special Reference to Oxaliplatin and Its Association to Chemotherapy-Induced Peripheral Neuropathy (CIPN). Transl Oncol. 2017 Aug;10(4):641-649. [Content Brief]
- [2]. Wang C. Mangafodipir trisodium (MnDPDP)-enhanced magnetic resonance imaging of the liver and pancreas. Acta Radiol Suppl. 1998;415:1-31. [Content Brief]
