1561-55-3
Chemical Structure
1,2-Di-O-tetradecyl-rac-glycerol
- CAS No.: 1561-55-3
- Formula:C31H64O3
- Molecular Weight:484.84
InChIKey: IAJHLVPJJCPWLF-UHFFFAOYSA-N
SMILES: OCC(COCCCCCCCCCCCCCC)OCCCCCCCCCCCCCC
Biological Activity: 1,2-Di-O-tetradecyl-rac-glycerol is a hydrophobic lipid precursor molecule that can be used to synthesize various cationic lipids and targeted lipid conjugates. 1,2-Di-O-tetradecyl-rac-glycerol encapsulates nucleic acids through electrostatic interactions to form lipid complexes, and efficiently delivers them into target cells via receptor-mediated endocytosis, thereby achieving gene expression or silencing. 1,2-Di-O-tetradecyl-rac-glycerol can be used in research on drug delivery and artificial biomembranes[1][2][3][4][5][6][7].
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1,2-Di-O-tetradecyl-rac-glycerol | 1,2-Di-O-tetradecyl-rac-glycerol is a hydrophobic lipid precursor molecule that can be used to synthesize various cationic lipids and targeted lipid conjugates. 1,2-Di-O-tetradecyl-rac-glycerol encapsulates nucleic acids through electrostatic interactions to form lipid complexes, and efficiently delivers them into target cells via receptor-mediated endocytosis, thereby achieving gene expression or silencing. 1,2-Di-O-tetradecyl-rac-glycerol can be used in research on drug delivery and artificial biomembranes. | |||||||||||||||||||||
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References
- [1]. Markov OO, et al. Novel cationic liposomes provide highly efficient delivery of DNA and RNA into dendritic cell progenitors and their immature offsets. Journal of controlled release : official journal of the Controlled Release Society. 2012 Jun 10;160(2):200-10.
- [2]. Shmendel E, et al. Effects of spacers within a series of novel folate-containing lipoconjugates on the targeted delivery of nucleic acids. Journal of Drug Delivery Science and Technology. 2020 Jun 1;57:101609.
- [3]. Lipenskiy VМ, et al. Synthesis of sulfur-containing precursor of targeted lipoconjugates. Chemical Bulletin. 2025 Nov 15;8(3):4.
- [4]. Maslov MA, et al. Synthesis of cationic lipid transfection agents with O, O-or N, O-acetal linkages. Russian Journal of Bioorganic Chemistry. 2009 Sep;35(5):628-32.
- [5]. Ivanova EA, et al. Synthesis of bivalent neogalactolipids via modified Staudinger reaction. RSC advances. 2012 May 15;2(11):4600-2.
- [6]. Ivanova EA, et al. Novel bivalent spermine-based neutral neogalactolipids for modular gene delivery systems. RSC advances. 2015 Nov 2;5(113):93262-6.
- [7]. Maslov MA, et al. Synthesis and transfection activity of novel galactosylated polycationic lipid. Bioorganic & medicinal chemistry letters. 2011 May 15;21(10):2937-40.
