1677668-27-7
1677668-27-7
Chemical Structure
GNE-6468
- CAS No.: 1677668-27-7
- Formula:C23H16ClN3O4
- Molecular Weight:433.84
IUPAC Name: 4-(6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl)-2-hydroxybenzoic acid
InChIKey: GIYKJPISDNWSJD-UHFFFAOYSA-N
SMILES: OC1=CC(C2=C3N(C(C(C4=C(C5CC5)C=CC=C4Cl)=O)=N2)C=CC=N3)=CC=C1C(O)=O
Biological Activity: GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC[1].
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GNE-6468 | 98.02% | GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC. | ||||||||||||||||||||
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