175014-68-3
Chemical Structure
hCAI/II-IN-9
- CAS No.: 175014-68-3
- Formula:C13H12N4O5S
- Molecular Weight:336.32
IUPAC Name: 4-(3-(4-nitrophenyl)ureido)benzenesulfonamide
InChIKey: UUZKJPOBWQCXEM-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(NC(NC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)(N)=O
Biological Activity: hCAI/II-IN-9 is a carbonic anhydrase inhibitor with inhibitory activity against human carbonic anhydrase isoforms I, II, IX, and XII. The inhibition constants (Ki) of hCAI/II-IN-9 for hCA I are in the range of 7.9-894 nM, for hCA II are in the range of 7.5-1645 nM, for hCA IX are in the range of 5.0-240 nM, and for hCA XII are in the range of 0.47-2.83 nM. hCAI/II-IN-9 may have potential applications in inhibiting a variety of pathologies involving these carbonic anhydrase isoforms[1].
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hCAI/II-IN-9 | hCAI/II-IN-9 is a carbonic anhydrase inhibitor with inhibitory activity against human carbonic anhydrase isoforms I, II, IX, and XII. The inhibition constants (Ki) of hCAI/II-IN-9 for hCA I are in the range of 7.9-894 nM, for hCA II are in the range of 7.5-1645 nM, for hCA IX are in the range of 5.0-240 nM, and for hCA XII are in the range of 0.47-2.83 nM. hCAI/II-IN-9 may have potential applications in inhibiting a variety of pathologies involving these carbonic anhydrase isoforms. | |||||||||||||||||||||
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Keywords
