18833-13-1
Chemical Structure
Acefylline piperazine
Synonym(s): Theophyllineacetic acid piperazine; Theophylline-7-acetic acid piperazine
- CAS No.: 18833-13-1
- Formula:C9H10N4O4.xC4H10N2
- Molecular Weight:N/A
SMILES: O=C(CN1C=NC2=C1C(N(C)C(N2C)=O)=O)O.N3CCNCC3.[x]
Biological Activity: Acefylline (Theophyllineacetic acid) piperazine, a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline piperazine is a peptidylarginine deiminase (PAD) activator. Acefylline piperazine is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline piperazine can be used in asthma research[1][2][3].
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Acefylline piperazine | Acefylline (Theophyllineacetic acid) piperazine, a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline piperazine is a peptidylarginine deiminase (PAD) activator. Acefylline piperazine is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline piperazine can be used in asthma research. | |||||||||||||||||||||
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- [1]. Ferretti C, et al. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol-theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14(1):31-6. [Content Brief]
- [2]. Méchin MC, et, al. Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. J Dermatol Sci. 2016 Feb;81(2):101-6. [Content Brief]
- [3]. Tsvetkova B, Tencheva J, Peikov P. Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharm. 2006 Jun;56(2):251-7. PMID: 16613730. [Content Brief]
Keywords
