1950634-92-0
1950634-92-0
Chemical Structure
dBET6
- CAS No.: 1950634-92-0
- Formula:C42H45ClN8O7S
- Molecular Weight:841.37
IUPAC Name: 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide
InChIKey: JGQPZPLJOBHHBK-UFXYQILXSA-N
SMILES: O=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
Biological Activity: dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity.
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dBET6 | 99.90% | dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity. | ||||||||||||||||||||
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dBET6 (Standard) | ≥98% | dBET6 (Standard) is the analytical standard of dBET6 (HY-112588). This product is intended for research and analytical applications. dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity. | ||||||||||||||||||||
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