195720-26-4
195720-26-4
Chemical Structure
SJ-3366
Synonym(s): IQP-0410
- CAS No.: 195720-26-4
- Formula:C21H24N2O3
- Molecular Weight:352.43
IUPAC Name: 1-(cyclopent-3-en-1-ylmethyl)-6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione
InChIKey: BEMROAADXJFLBI-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC)=C(N1CC2CC=CC2)C(C3=CC(C)=CC(C)=C3)=O)=O
Biological Activity: SJ-3366 (IQP-0410) is a potent inhibitor of HIV nonnucleoside reverse transcriptase[1]. SJ-3366 (IQP-0410) inhibits HIV at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism[2].
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SJ-3366 | SJ-3366 (IQP-0410) is a potent inhibitor of HIV nonnucleoside reverse transcriptase. SJ-3366 (IQP-0410) inhibits HIV at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism. | |||||||||||||||||||||
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References
- [1]. Ham AS, Lustig W, Yang L, Boczar A, Buckheit KW, Buckheit RW Jr. In vitro and ex vivo evaluations on transdermal delivery of the HIV inhibitor IQP-0410. PLoS One. 2013;8(9):e75306. [Content Brief]
- [2]. Buckheit RW Jr, Watson Buckheit K, Sturdevant CB, Buckheit RW 3rd. Selection and characterization of viruses resistant to the dual acting pyrimidinedione entry and non-nucleoside reverse transcriptase inhibitor IQP-0410. Antiviral Res. 2013;100(2):382-391 [Content Brief]
