199875-71-3
Chemical Structure
Eicosapentaenoyl serotonin
Synonym(s): EPA-5-HT
- CAS No.: 199875-71-3
- Formula:C30H40N2O2
- Molecular Weight:460.65
IUPAC Name: (5Z,8Z,11Z,14Z,17Z)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)icosa-5,8,11,14,17-pentaenamide
InChIKey: RYPAMQYLBIIZHL-JLNKQSITSA-N
SMILES: O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)NCCC1=CNC2=CC=C(C=C12)O
Biological Activity: Eicosapentaenoyl serotonin (EPA-5-HT) is an endogenous fatty acid-serotonin conjugate lipid mediator. Eicosapentaenoyl serotonin acts as an inhibitor of fatty acid amide hydrolase (FAAH). Eicosapentaenoyl serotonin suppresses IL-17 release in Concanavalin A (HY-P2149)-stimulated human peripheral blood mononuclear cells. Eicosapentaenoyl serotonin is regulated by polyunsaturated fatty acids and modulates intestinal immunity and Th17 signaling. Eicosapentaenoyl serotonin can be used for the study of inflammatory bowel disease-related mechanisms[1][2].
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Eicosapentaenoyl serotonin | 99.0% | Eicosapentaenoyl serotonin (EPA-5-HT) is an endogenous fatty acid-serotonin conjugate lipid mediator. Eicosapentaenoyl serotonin acts as an inhibitor of fatty acid amide hydrolase (FAAH). Eicosapentaenoyl serotonin suppresses IL-17 release in Concanavalin A (HY-P2149)-stimulated human peripheral blood mononuclear cells. Eicosapentaenoyl serotonin is regulated by polyunsaturated fatty acids and modulates intestinal immunity and Th17 signaling. Eicosapentaenoyl serotonin can be used for the study of inflammatory bowel disease-related mechanisms. | ||||||||||||||||||||
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- [1]. Verhoeckx KC, et al. Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract. Biochim Biophys Acta. 2011;1811(10):578-586. [Content Brief]
- [2]. Wang Y, et al. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862(9):823-831. [Content Brief]
Keywords
