2153474-85-0
2153474-85-0
Chemical Structure
PF-05661014
- CAS No.: 2153474-85-0
- Formula:C17H16N4O3S2
- Molecular Weight:388.46
IUPAC Name: 4-(3-benzylureido)-N-(thiazol-2-yl)benzenesulfonamide
InChIKey: BMCSKUJQKUYLNE-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(NC(NCC2=CC=CC=C2)=O)C=C1)(NC3=NC=CS3)=O
Biological Activity: PF-05661014, a desmethyl analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing inactivated channels via interaction with D4 VSD. PF-05661014 can be used for research of sodium channel modulation[1].
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PF-05661014 | 99.56% | PF-05661014, a desmethyl analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing inactivated channels via interaction with D4 VSD. PF-05661014 can be used for research of sodium channel modulation. | ||||||||||||||||||||
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References
- [1]. Wang L, et al. Retracted: Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation. British Journal of Pharmacology, volume 172(20): 4905-4918, published in October 2015; DOI 10.1111/bph.13259. Br J Pharmacol. 2018 Jul;175(13):2712. [Content Brief]
Keywords
