224170-09-6
224170-09-6
Chemical Structure
U-101958 maleate
Synonym(s): PNU-101958 maleate
- CAS No.: 224170-09-6
- Formula:C25H33N3O5
- Molecular Weight:455.55
IUPAC Name: N-(1-benzylpiperidin-4-yl)-3-isopropoxy-N-methylpyridin-2-amine maleate
InChIKey: KPYPLDPMBWPEBO-BTJKTKAUSA-N
SMILES: CC(C)OC1=CC=CN=C1N(C)C2CCN(CC2)CC3=CC=CC=C3.O=C(/C=C\C(O)=O)O
Biological Activity: U-101958 (PNU-101958) maleate is a highly selective ligand and antagonist for dopamine D4 receptor, with an IC50 of 2.7 nM. U-101958 maleate behaves as an agonist in HEK-293 cells expressing the human recombinant D4.4 receptor. U-101958 maleate is an antipsychotic[1][2].
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U-101958 maleate | U-101958 (PNU-101958) maleate is a highly selective ligand and antagonist for dopamine D4 receptor, with an IC50 of 2.7 nM. U-101958 maleate behaves as an agonist in HEK-293 cells expressing the human recombinant D4.4 receptor. U-101958 maleate is an antipsychotic. | |||||||||||||||||||||
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References
- [1]. Gazi L, et al. The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor. Br J Pharmacol. 1998 Jul;124(5):889-96. [Content Brief]
- [2]. De La Garza R 2nd, et al. [(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain. Synapse. 2000 Sep 1;37(3):232-44. [Content Brief]
