2279171-34-3
Chemical Structure
ddhCTP
- CAS No.: 2279171-34-3
- Formula:C9H14N3O13P3
- Molecular Weight:465.14
IUPAC Name: ((4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-4,5-dihydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: DGUQXKKDZHTKIE-HTRCEHHLSA-N
SMILES: NC(C=CN1[C@@H]2OC(COP(OP(OP(O)(O)=O)(O)=O)(O)=O)=C[C@H]2O)=NC1=O
Biological Activity: ddhCTP is an endogenously produced pyrimidine base analog with a Kd of 17.0 nM for LLDH and an IC50 of 55.8 μM for GAPDH. By inhibiting key metabolic enzymes such as GAPDH, ddhCTP reduces glycolytic flux and shifts metabolic flow toward the pentose phosphate pathway, thereby regulating the redox balance of cells. As a competitive CTP analog, ddhCTP terminates RNA synthesis by flavivirus RdRps and SARS-CoV-2 RdRp, and inhibits Zika virus replication in vivo. ddhCTP can be used in studies related to viral infections, COVID-19 and Zika virus infections.[1][2]
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ddhCTP | ddhCTP is an endogenously produced pyrimidine base analog with a Kd of 17.0 nM for LLDH and an IC50 of 55.8 μM for GAPDH. By inhibiting key metabolic enzymes such as GAPDH, ddhCTP reduces glycolytic flux and shifts metabolic flow toward the pentose phosphate pathway, thereby regulating the redox balance of cells. As a competitive CTP analog, ddhCTP terminates RNA synthesis by flavivirus RdRps and SARS-CoV-2 RdRp, and inhibits Zika virus replication in vivo. ddhCTP can be used in studies related to viral infections, COVID-19 and Zika virus infections. | |||||||||||||||||||||
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- [1]. Honarmand Ebrahimi K, et al. ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD+ -dependent activity of enzymes to modulate metabolism. FEBS Lett. 2020;594(10):1631-1644. [Content Brief]
- [2]. Ciardullo G, et al. Viral RNA Replication Suppression of SARS-CoV-2: Atomistic Insights into Inhibition Mechanisms of RdRp Machinery by ddhCTP. J Chem Inf Model. 2024;64(5):1593-1604. [Content Brief]
Keywords
