228123-15-7
Chemical Structure
AH-1058
- CAS No.: 228123-15-7
- Formula:C30H29ClN2O3
- Molecular Weight:501.02
IUPAC Name: (E)-4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-(3-(3-methoxy-2-nitrophenyl)allyl)piperidine hydrochloride
InChIKey: HUGNVHKJRQLOAZ-RVDQCCQOSA-N
SMILES: O=[N+]([O-])C1=C(C=CC=C1/C=C/CN2CC/C(CC2)=C3C4=CC=CC=C4C=CC5=CC=CC=C/35)OC.Cl
Biological Activity: AH-1058 is a newly synthesized antiarrhythmic agent that exhibits significant antiarrhythmic activity by delaying premature ventricular complexes and ventricular fibrillation in experimental arrhythmia models. AH-1058 effectively inhibits both ventricular tachycardia and ventricular fibrillation in the reperfusion-induced arrhythmia model in rats. AH-1058 demonstrates potent calcium channel-blocking effects, suppressing L-type Ca2+ currents in isolated cardiomyocytes.
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AH-1058 | AH-1058 is a newly synthesized antiarrhythmic agent that exhibits significant antiarrhythmic activity by delaying premature ventricular complexes and ventricular fibrillation in experimental arrhythmia models. AH-1058 effectively inhibits both ventricular tachycardia and ventricular fibrillation in the reperfusion-induced arrhythmia model in rats. AH-1058 demonstrates potent calcium channel-blocking effects, suppressing L-type Ca2+ currents in isolated cardiomyocytes. | |||||||||||||||||||||
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