2413958-04-8
Chemical Structure
EGFR kinase inhibitor 1
- CAS No.: 2413958-04-8
- Formula:C30H31N7O2
- Molecular Weight:521.61
IUPAC Name: N-(2-(2-((dimethylamino)methyl)-1H-pyrrol-1-yl)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
InChIKey: YIYTWDRDNVPEHZ-UHFFFAOYSA-N
SMILES: C=CC(NC1=C(C=C(C(NC2=NC(C3=CN(C4=C3C=CC=C4)C)=CC=N2)=C1)OC)N5C=CC=C5CN(C)C)=O
Biological Activity: EGFR kinase inhibitor 1 is a potent EGFR inhibitor with IC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity[1].
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EGFR kinase inhibitor 1 | EGFR kinase inhibitor 1 is a potent EGFR inhibitor with IC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity. | |||||||||||||||||||||
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