2477606-87-2
Chemical Structure
Aβ-IN-3
- CAS No.: 2477606-87-2
- Formula:C33H43N5O7
- Molecular Weight:621.72
IUPAC Name: ((7S,10S,13S,E)-13-((S)-2-amino-4-methylpentanamido)-10-benzyl-9,12-dioxo-2-oxa-8,11-diaza-1(1,4)-benzenacyclotetradecaphan-4-ene-7-carbonyl)-L-alanine
InChIKey: TYHQSXWPNRIHHQ-VLNZCUNHSA-N
SMILES: O=C([C@H](CC1=CC=C(OC/C=C/C[C@H](NC2=O)C(N[C@@H](C)C(O)=O)=O)C=C1)NC([C@@H](N)CC(C)C)=O)N[C@H]2CC3=CC=CC=C3
Biological Activity: Aβ-IN-3 (compound 1) is a potent amyloid β (Aβ) inhibitor. Aβ-IN-3 inhibits Aβ42 aggregation. However, Aβ-IN-3 can not alleviate the neurotoxicity of Aβ42 in SH-SY5Y cells. Aβ-IN-3 can not change the aggregation state of Aβ42 into a nontoxic one[1].
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Aβ-IN-3 | Aβ-IN-3 (compound 1) is a potent amyloid β (Aβ) inhibitor. Aβ-IN-3 inhibits Aβ42 aggregation. However, Aβ-IN-3 can not alleviate the neurotoxicity of Aβ42 in SH-SY5Y cells. Aβ-IN-3 can not change the aggregation state of Aβ42 into a nontoxic one. | |||||||||||||||||||||
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