2568277-84-7
2568277-84-7
Chemical Structure
PROTAC SMARCA2/4 degrader-5
- CAS No.: 2568277-84-7
- Formula:C56H65N11O5S
- Molecular Weight:1004.25
InChIKey: AYIKNPOLBLCBLM-TUJBAWDOSA-N
SMILES: NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6=CC=C(C=C6)C[C@@H]7CC[C@H](CC7)C(N[C@@H](C(C)(C)C)C(N8[C@@H](C[C@H](C8)O)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O)C=N5)C(CC4)C3
Biological Activity: PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 of 100-500 nM[1].
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PROTAC SMARCA2/4 degrader-5 | PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 of 100-500 nM. | |||||||||||||||||||||
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