2640000-92-4
Chemical Structure
Iboxamycin
- CAS No.: 2640000-92-4
- Formula:C22H39ClN2O6S
- Molecular Weight:495.07
IUPAC Name: (4S,5aS,8S,8aR)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-4-isobutyloctahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide
InChIKey: JPCLUJPDWMBCAA-SUTQZAMLSA-N
SMILES: O=C([C@@H](NC1)[C@@](OCC2)([H])[C@@]1([H])C[C@@H]2CC(C)C)N[C@@H]([C@@]([C@@H]([C@@H]3O)O)([H])O[C@@H]([C@@H]3O)SC)[C@@H](Cl)C
Biological Activity: Iboxamycin is a potent antibiotic candidate bearing a fused bicyclic amino acid residue. Iboxamycin is orally bioavailable, safe and effective in researching both Gram-positive and Gram-negative bacterial infections in mice[1][2].
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Iboxamycin | Iboxamycin is a potent antibiotic candidate bearing a fused bicyclic amino acid residue. Iboxamycin is orally bioavailable, safe and effective in researching both Gram-positive and Gram-negative bacterial infections in mice. | |||||||||||||||||||||
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References
- [1]. Mason JD, et al. Practical Gram-Scale Synthesis of Iboxamycin, a Potent Antibiotic Candidate. J Am Chem Soc. 2021;143(29):11019-11025. [Content Brief]
- [2]. Mitcheltree MJ, et al. A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature. 2021;599(7885):507-512. [Content Brief]
