2653994-10-4
2653994-10-4
Chemical Structure
(S)-Opnurasib
Synonym(s): (S)-JDQ-443; (S)-NVP-JDQ443
- CAS No.: 2653994-10-4
- Formula:C29H28ClN7O
- Molecular Weight:526.03
InChIKey: AZUYLZMQTIKGSC-UHFFFAOYSA-N
SMILES: O=C(C=C)N1CC2(C1)CC(N3N=C(C4=CC=C5C(C=NN5C)=C4)[C@@]([C@@]6=C(Cl)C(C)=CC7=C6C=NN7)=C3C)C2
Biological Activity: (S)-Opnurasib ((S)-JDQ-443; (S)-NVP-JDQ443) is an isomer of Opnurasib (HY-139612). Opnurasib is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). Opnurasib shows antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-Opnurasib | 98.11% | (S)-Opnurasib ((S)-JDQ-443; (S)-NVP-JDQ443) is an isomer of Opnurasib (HY-139612). Opnurasib is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). Opnurasib shows antitumor activity. | ||||||||||||||||||||
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References
- [1]. LIU BO, et al. PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS. Patent WO2021120890A1.
- [2]. Weiss A, Lorthiois E, Barys L, et al. Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent and Selective, Covalent Oral Inhibitor of KRASG12C. Cancer Discov. 2022;candisc.0158.2022. [Content Brief]
