2733145-73-6
2733145-73-6
Chemical Structure
Vismodegib-d7
- CAS No.: 2733145-73-6
- Formula:C19H7D7Cl2N2O3S
- Molecular Weight:428.34
InChIKey: BPQMGSKTAYIVFO-DHHYOMDSSA-N
SMILES: ClC1=C(C([2H])=C(C([2H])=C1C2=C(C([2H])=C(C([2H])=N2)[2H])[2H])NC(C3=C(C=C(C=C3)S(C)(=O)=O)Cl)=O)[2H]
Biological Activity: Vismodegib-d7 is deuterium labeled Vismodegib. Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively[1][2].
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Vismodegib-d7 | Vismodegib-d7 is deuterium labeled Vismodegib. Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively. | |||||||||||||||||||||
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Vismodegib (Standard) | ≥98% | Vismodegib (Standard) is the analytical standard of Vismodegib. This product is intended for research and analytical applications. Vismodegib (GDC-0449) is a BBB-permeable and orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively. | ||||||||||||||||||||
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Vismodegib-d4 | Vismodegib-d4 is deuterium labeled Vismodegib. Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively. | |||||||||||||||||||||
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Vismodegib | 99.90% | Vismodegib (GDC-0449) is a BBB-permeable and orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively. | ||||||||||||||||||||
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References
