2750413-88-6
Chemical Structure
CCG-271423
- CAS No.: 2750413-88-6
- Formula:C28H26N4O3
- Molecular Weight:466.53
IUPAC Name: (R,Z)-3-((3,5-dimethyl-4-(prop-2-yn-1-ylcarbamoyl)-1H-pyrrol-2-yl)methylene)-2-oxo-N-(1-phenylethyl)indoline-5-carboxamide
InChIKey: KIHFNNZABDKAOK-JVDNRXPZSA-N
SMILES: O=C(/C(C1=C2)=C\C3=C(C(C(NCC#C)=O)=C(N3)C)C)NC1=CC=C2C(N[C@@H](C4=CC=CC=C4)C)=O
Biological Activity: CCG-271423 is a potent and selective GRK5 inhibitor with IC50 values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca2+ transience[1]. CCG-271423 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CCG-271423 | CCG-271423 is a potent and selective GRK5 inhibitor with IC50 values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca2+ transience. CCG-271423 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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Keywords
