2834758-29-9
Chemical Structure
AChE/BuChE/MAO-B-IN-1
- CAS No.: 2834758-29-9
- Formula:C17H23NO3
- Molecular Weight:289.37
IUPAC Name: 6-(2-(azepan-1-yl)ethoxy)chroman-4-one
InChIKey: KZJOEKCJUWZUDR-UHFFFAOYSA-N
SMILES: O=C1CCOC2=C1C=C(OCCN3CCCCCC3)C=C2
Biological Activity: AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC50s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ1 and σ2 receptors with Ki values of 42.8 nM (human σ1 receptor) and 191 nM (rat σ2 receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research[1].
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AChE/BuChE/MAO-B-IN-1 | AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC50s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ1 and σ2 receptors with Ki values of 42.8 nM (human σ1 receptor) and 191 nM (rat σ2 receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research. | |||||||||||||||||||||
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Keywords
