2. Neuronal Signaling
  3. Cholinesterase (ChE) Monoamine Oxidase
  4. AChE/BuChE/MAO-B-IN-1

AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC50s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ1 and σ2 receptors with Ki values of 42.8 nM (human σ1 receptor) and 191 nM (rat σ2 receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research.

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AChE/BuChE/MAO-B-IN-1 Chemical Structure

AChE/BuChE/MAO-B-IN-1 Chemical Structure

CAS No. : 2834758-29-9

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AChE/BuChE/MAO-B-IN-1 Related Antibodies

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Description

AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC50s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ1 and σ2 receptors with Ki values of 42.8 nM (human σ1 receptor) and 191 nM (rat σ2 receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research[1].

IC50 & Target[1]

hAChE

4.8 μM (IC50)

hBCHE

13.7 μM (IC50)

hMAO-B

1.11 μM (IC50)

Molecular Weight

289.37

Formula

C17H23NO3
CAS No.
SMILES

O=C1CCOC2=C1C=C(OCCN3CCCCCC3)C=C2
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Purity & Documentation
References
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AChE/BuChE/MAO-B-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BuChE/MAO-B-IN-12834758-29-9Cholinesterase (ChE)Monoamine OxidaseMAOAlzheimer’s diseasechromanonesmultineurotarget agentshuman cholinesterasesInhibitorinhibitorinhibit

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