2924344-29-4
2924344-29-4
Chemical Structure
TRK-IN-23
- CAS No.: 2924344-29-4
- Formula:C20H17FN4O2
- Molecular Weight:364.37
IUPAC Name: (Z)-3-((1H-imidazol-5-yl)methylene)-5-((5-fluoro-2-methoxybenzyl)amino)indolin-2-one
InChIKey: ZSFJFWHLJJYXII-IUXPMGMMSA-N
SMILES: COC1=CC=C(C=C1CNC2=CC3=C(NC(/C3=C\C4=CN=CN4)=O)C=C2)F
Biological Activity: TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].
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TRK-IN-23 | TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells. | |||||||||||||||||||||
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References
Keywords
