2978623-09-3
2978623-09-3
Chemical Structure
PD-L1/VISTA-IN-1
- CAS No.: 2978623-09-3
- Formula:C22H24N4O4
- Molecular Weight:408.45
InChIKey: QSHNMTVUJAVARU-IBGZPJMESA-N
SMILES: CC1=C(C=CC=C1C2=CC=CC=C2)NC3=NC(OC)=CC(CN[C@H](C(O)=O)CO)=N3
Biological Activity: PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA. PD-L1/VISTA-IN-1 can block the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity[1].
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PD-L1/VISTA-IN-1 | PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA. PD-L1/VISTA-IN-1 can block the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity. | |||||||||||||||||||||
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References
Keywords
