3022265-51-3
3022265-51-3
Chemical Structure
HSB401
- CAS No.: 3022265-51-3
- Formula:C26H28FN5O
- Molecular Weight:445.53
InChIKey: OBEIPKSYMAENPZ-UHFFFAOYSA-N
SMILES: CN(C)CCNC(C(C=C1)=CC(F)=C1C(C2=C3CCCC2)=NC4=C3C(C(C)=NN5)=C5C=C4)=O
Biological Activity: HSB401 is an orally active FLT3 inhibitor (IC50: 28, 5, 72, 51 nM for FLT3-WT, FLT3-D835Y, FLT3-ITD-F691L, FLT3-ITD, respectively). HSB401 downregulates FLT3 signaling and induces cell cycle arrest and apoptosis. HSB401 spares c-KIT inhibition, thereby reducing the risk of myelosuppression. HSB401 significantly suppresses tumor growth in the MV4-11 xenograft mouse model. HSB401 can be used for the research of acute myeloid leukemia[1].
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HSB401 | HSB401 is an orally active FLT3 inhibitor (IC50: 28, 5, 72, 51 nM for FLT3-WT, FLT3-D835Y, FLT3-ITD-F691L, FLT3-ITD, respectively). HSB401 downregulates FLT3 signaling and induces cell cycle arrest and apoptosis. HSB401 spares c-KIT inhibition, thereby reducing the risk of myelosuppression. HSB401 significantly suppresses tumor growth in the MV4-11 xenograft mouse model. HSB401 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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