3052736-47-4
Chemical Structure
COX-2/15-LOX-IN-3
- CAS No.: 3052736-47-4
- Formula:C25H24FN3O3S
- Molecular Weight:465.54
InChIKey: ADBHJTCBNSFXQH-UHFFFAOYSA-N
SMILES: COC1=C(OC)C(OC)=CC(C2=NC3=C(C(CCCC4)=C4S3)C(NC5=CC=C(F)C=C5)=N2)=C1
Biological Activity: COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity[1].
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COX-2/15-LOX-IN-3 | COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity. | |||||||||||||||||||||
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Keywords