3057582-20-1
3057582-20-1
Chemical Structure
PI3Kα-IN-32
- CAS No.: 3057582-20-1
- Formula:C20H18F5N5O2S
- Molecular Weight:487.45
InChIKey: XTUATCNNCIBVRQ-MRXNPFEDSA-N
SMILES: OC(C1)(C)CN1C(N=C2)=NC=C2NC(N[C@H](C3=C(C)C4=C(C(F)=CC(F)=C4)S3)C(F)(F)F)=O
Biological Activity: PI3Kα-IN-32 (Compound 11f) is a selective, orally active PI3Kα inhibitor, with an IC50 of 26.3 nM against PI3KαH1047R. PI3Kα-IN-32 inhibits AKT phosphorylation. PI3Kα-IN-32 exhibits anticancer activity against breast cancer. PI3Kα-IN-32 can be used in the research of HR+/HER2- breast cancer[1].
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PI3Kα-IN-32 | PI3Kα-IN-32 (Compound 11f) is a selective, orally active PI3Kα inhibitor, with an IC50 of 26.3 nM against PI3KαH1047R. PI3Kα-IN-32 inhibits AKT phosphorylation. PI3Kα-IN-32 exhibits anticancer activity against breast cancer. PI3Kα-IN-32 can be used in the research of HR+/HER2- breast cancer. | |||||||||||||||||||||
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References
Keywords
