3064686-59-2
3064686-59-2
Chemical Structure
Sulfonadyn-47
- CAS 番号: 3064686-59-2
- Formula:C22H23BrN2O2S
- Molecular Weight:459.40
InChIKey: ZYCDTZNHEUVRAI-GQCTYLIASA-N
SMILES: BrC1=CC=C(C=C1)/C=C/CNCCCNS(=O)(C2=C3C=CC=CC3=CC=C2)=O
Biological Activity: Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC50 values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure[1].
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Sulfonadyn-47 | Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC50 values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure. | |||||||||||||||||||||
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Keywords
