3075119-33-1
3075119-33-1
Chemical Structure
FAP-IN-8
- CAS No.: 3075119-33-1
- Formula:C32H36N8O6
- Molecular Weight:628.68
InChIKey: VFIKGLWRODDOLK-MUUNZHRXSA-N
SMILES: O=C(C1=CC=NC2=C1C=C(C=C2)OCCCN3CCOCC3)NCC(N4[C@H](CCC4)C(C(NCN5C6=C(N=N5)C=CC=C6)=O)=O)=O
Biological Activity: FAP-IN-8 (Compound 12i) is a potent inhibitor of PREP and FAP, with pIC50 values of 8.99 and 10.08 for FAP and PREP, and IC50 values of 1 and 0.08 nM, respectively. FAP-IN-8 may be used in cancer research[1].
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FAP-IN-8 | FAP-IN-8 (Compound 12i) is a potent inhibitor of PREP and FAP, with pIC50 values of 8.99 and 10.08 for FAP and PREP, and IC50 values of 1 and 0.08 nM, respectively. FAP-IN-8 may be used in cancer research. | |||||||||||||||||||||
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References
- [1]. Brzeminski P, et al. Structure-Property Investigation of New "KetoFAPI" Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential. J Med Chem. 2025 Oct 23;68(20):21739-21765. [Content Brief]
