FAP-IN-8
FAP-IN-8 (Compound 12i) is a potent inhibitor of PREP and FAP, with pIC50 values of 8.99 and 10.08 for FAP and PREP, and IC50 values of 1 and 0.08 nM, respectively. FAP-IN-8 may be used in cancer research.
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- CAS. Nr.: 3075119-33-1
- Formel: C32H36N8O6
- Molecular Weight:628.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 3075119-33-1
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Molecular Weight 628.68
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Formel C32H36N8O6
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SMILES
O=C(C1=CC=NC2=C1C=C(C=C2)OCCCN3CCOCC3)NCC(N4[C@H](CCC4)C(C(NCN5C6=C(N=N5)C=CC=C6)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
[1]. Brzeminski P, et al. Structure-Property Investigation of New "KetoFAPI" Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential. J Med Chem. 2025 Oct 23;68(20):21739-21765. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FAP-IN-8 Related Classifications
HY-178981 Related Classifications
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