3084436-73-4
Chemical Structure
AR antagonist 18
- CAS No.: 3084436-73-4
- Formula:C19H19N5OS2
- Molecular Weight:397.52
InChIKey: GIRJVQPLQOOLRC-UHFFFAOYSA-N
SMILES: CSC1=CC(N2C(N(CC3=CC=C(C)N=C3)C(C)(C)C2=O)=S)=CN=C1C#N
Biological Activity: AR antagonist 18 is a selective androgen receptor antagonist with an IC50 of 20.6 nM. AR antagonist 18 exerts AR transcriptional inhibitory effects by interacting with AR residues Phe765 and Trp742 via conformational flexibility. AR antagonist 18 acts as a hair growth inducer, and exhibits low systemic exposure and reduced distribution to male reproductive organs in a mouse model of hair growth. AR antagonist 18 can be used for research on androgenetic alopecia[1].
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AR antagonist 18 | AR antagonist 18 is a selective androgen receptor antagonist with an IC50 of 20.6 nM. AR antagonist 18 exerts AR transcriptional inhibitory effects by interacting with AR residues Phe765 and Trp742 via conformational flexibility. AR antagonist 18 acts as a hair growth inducer, and exhibits low systemic exposure and reduced distribution to male reproductive organs in a mouse model of hair growth. AR antagonist 18 can be used for research on androgenetic alopecia. | |||||||||||||||||||||
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Keywords
