3102293-90-0
3102293-90-0
Chemical Structure
Syk-IN-16
- CAS No.: 3102293-90-0
- Formula:C28H32N6O4
- Molecular Weight:516.59
InChIKey: LMZNOZNYFZQHAM-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C2N=C(NC2=C1)NC3=CC=C(C=C3)N4CCN(CC4)C)C5=CC(OC)=C(C(OC)=C5)OC
Biological Activity: Syk-IN-16 is a spleen tyrosine kinase (SYK) inhibitor with an IC50 of 16.0 nM. Syk-IN-16 exerts antiproliferative effects, induces cell apoptosis, inhibits cell migration and increases DNA damage in cancer cells. Syk-IN-16 suppresses tumor growth in xenograft models without obvious toxicity. Syk-IN-16 can be used for the research of triple-negative breast cancer[1].
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Syk-IN-16 | Syk-IN-16 is a spleen tyrosine kinase (SYK) inhibitor with an IC50 of 16.0 nM. Syk-IN-16 exerts antiproliferative effects, induces cell apoptosis, inhibits cell migration and increases DNA damage in cancer cells. Syk-IN-16 suppresses tumor growth in xenograft models without obvious toxicity. Syk-IN-16 can be used for the research of triple-negative breast cancer. | |||||||||||||||||||||
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References
Keywords
