3120497-79-9
Chemical Structure
AKR1C3-IN-17
- CAS No.: 3120497-79-9
- Formula:C38H43F2N7O11
- Molecular Weight:811.79
InChIKey: MTEGMVHIFRAMCD-PGVMJHPASA-N
SMILES: COC1=CC(C(N[C@@H](C(C)C)C(N[C@H](C(NC2=NC(N(C=C2)[C@@H]3O[C@@H]([C@H](C3(F)F)O)CO)=O)=O)C)=O)=O)=CC(NC(C4=CC=CC=C4OCC5=C(ON=C5C)C)=O)=C1
Biological Activity: AKR1C3-IN-17 is a cathepsin B (CTSB)-activated small molecule-drug conjugate targeting AKR1C3 with an IC50 of 9 nM. AKR1C3-IN-17 is cleaved by CTSB to release the payload Gemcitabine (HY-17026). AKR1C3-IN-17 induces apoptosis and shows antitumor activity in mice. AKR1C3-IN-17 can be used for the study of hepatocellular carcinoma[1].
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AKR1C3-IN-17 | AKR1C3-IN-17 is a cathepsin B (CTSB)-activated small molecule-drug conjugate targeting AKR1C3 with an IC50 of 9 nM. AKR1C3-IN-17 is cleaved by CTSB to release the payload Gemcitabine (HY-17026). AKR1C3-IN-17 induces apoptosis and shows antitumor activity in mice. AKR1C3-IN-17 can be used for the study of hepatocellular carcinoma. | |||||||||||||||||||||
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Keywords
