489-21-4
Chemical Structure
Sarkomycin
- CAS No.: 489-21-4
- Formula:C7H8O3
- Molecular Weight:140.14
InChIKey: ILFPCMXTASDZKM-RXMQYKEDSA-N
SMILES: OC([C@H]1C(C(CC1)=O)=C)=O
Biological Activity: Sarkomycin is a glutathione-targeting cytotoxic agent and antibacterial agent. Sarkomycin forms an addition product with glutathione, thereby reducing intracellular glutathione levels. Sarkomycin can induce cytoplasmic vacuolation, mitochondrial damage, cytoplasmic deformation, metaphase arrest, chromosomal abnormalities, nuclear degeneration, and nuclear fragmentation; it also modulates amino acid metabolism. Sarkomycin also inhibits anaerobic fermentation in affected cells in mice and inhibits cell growth in tissue culture, leading to the disappearance of mitotic cells, cell degeneration, and cell detachment from the glass surface. Sarkomycin can be used in research related to Yoshida ascites tumor, Ehrlich ascites tumor, Ehrlich carcinoma, and Yoshida rat sarcoma[1][2][3].
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Sarkomycin | Sarkomycin is a glutathione-targeting cytotoxic agent and antibacterial agent. Sarkomycin forms an addition product with glutathione, thereby reducing intracellular glutathione levels. Sarkomycin can induce cytoplasmic vacuolation, mitochondrial damage, cytoplasmic deformation, metaphase arrest, chromosomal abnormalities, nuclear degeneration, and nuclear fragmentation; it also modulates amino acid metabolism. Sarkomycin also inhibits anaerobic fermentation in affected cells in mice and inhibits cell growth in tissue culture, leading to the disappearance of mitotic cells, cell degeneration, and cell detachment from the glass surface. Sarkomycin can be used in research related to Yoshida ascites tumor, Ehrlich ascites tumor, Ehrlich carcinoma, and Yoshida rat sarcoma. | |||||||||||||||||||||
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References
- [1]. Roberts E, et al. Free amino acids in growing and regressing ascites cell tumors: host resistance and chemical agents[J]. Cancer research, 1956, 16(10_Part_1): 970-978.
- [2]. Hara T, et al. Studies on Sarkomycin. VII Effects of Sarkomycin and Related Compounds on the Anaerobic Fermentation of Ehrlich Ascites Carcinoma Cells of Mice[J]. The Journal of Antibiotics, Series A, 1956, 9(5): 191-192.
- [3]. Takeuchi T, et al. On antitumor effect of sarkomycin-INH[J]. The Journal of Antibiotics, Series A, 1958, 11(5): 212-216.
