519-67-5
519-67-5
Chemical Structure
Atromentin
- CAS. Nr.: 519-67-5
- Formula:C18H12O6
- Molecular Weight:324.29
IUPAC Name: 3',4,4'',6'-tetrahydroxy-[1,1':4',1''-terphenyl]-2',5'-dione
InChIKey: FKQQKMGWCJGUCS-UHFFFAOYSA-N
SMILES: O=C1C(O)=C(C(=O)C(O)=C1C=2C=CC(O)=CC2)C=3C=CC(O)=CC3
Biological Activity: Atromentin, a phthalide derivative that can be isolated from the wood fungus Hypoxylon fendleri BCC32408, is a selective enoyl-ACP reductase FabK inhibitor with an IC50 of 0.24 μM. Atromentin exhibits selectivity over FabI. Atromentin can be used for antimicrobial research[1][2].
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Atromentin | Atromentin, a phthalide derivative that can be isolated from the wood fungus Hypoxylon fendleri BCC32408, is a selective enoyl-ACP reductase FabK inhibitor with an IC50 of 0.24 μM. Atromentin exhibits selectivity over FabI. Atromentin can be used for antimicrobial research. | |||||||||||||||||||||
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References
- [1]. Zheng CJ, et al. Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae. J Antibiot (Tokyo). 2006 Dec;59(12):808-12. [Content Brief]
- [2]. Intaraudom C, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353. [Content Brief]
Keywords
