61230-27-1
Chemical Structure
Feldamycin
- CAS No.: 61230-27-1
- Formula:C17H25N7O5
- Molecular Weight:407.42
InChIKey: LUOBEJSTJAVJPL-UHFFFAOYSA-N
SMILES: O=C(C(CC1=CN=CN1)NC(C(C(O)=O)NC(C(CC2=CN=CN2)NC)=O)C)O
Biological Activity: Feldamycin is an antibacterial agent. Feldamycin inhibits highly purified Escherichia coli RNA polymerase, semi-conservative DNA replication, and the integration of 34S DNA fragments into larger DNA, and causes the accumulation of a 34S DNA species during replication. Feldamycin inhibits melanin synthesis and leukemia cell growth, and possesses antibacterial activity. Feldamycin can be used in research related to bacterial infections, leukemia, and melanoma[1][2][3].
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Feldamycin | Feldamycin is an antibacterial agent. Feldamycin inhibits highly purified Escherichia coli RNA polymerase, semi-conservative DNA replication, and the integration of 34S DNA fragments into larger DNA, and causes the accumulation of a 34S DNA species during replication. Feldamycin inhibits melanin synthesis and leukemia cell growth, and possesses antibacterial activity. Feldamycin can be used in research related to bacterial infections, leukemia, and melanoma. | |||||||||||||||||||||
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References
- [1]. Reusser F, et al. Ficellomycin and feldamycin; inhibitors of bacterial semiconservative DNA replication. Biochemistry. 1977 Jul 26;16(15):3406-12.
- [2]. Imae K, et al. Synthesis, stereochemistry, and biological properties of the depigmenting agents, melanostatin, feldamycin and analogs. J Antibiot (Tokyo). 1991 Jan;44(1):76-85.
- [3]. Argoudelis AD, et al. Antibiotics produced by Streptomyces ficellus II. Feldamycin and nojirimycin. The Journal of antibiotics. 1976 Oct;29(10):1007-14.
