6563-66-2
Chemical Structure
5,6,7-Trihydroxy-4'-methoxyflavone
Synonym(s): 4'-O-Methylscutellarein
- CAS No.: 6563-66-2
- Formula:C16H12O6
- Molecular Weight:300.26
IUPAC Name: 5,6,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChIKey: XVMMEYCPXZYLAI-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=C(C(O)=C13)O
Biological Activity: 5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC50 value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H2O2-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders[1][2].
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5,6,7-Trihydroxy-4'-methoxyflavone | 5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC50 value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H2O2-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders. | |||||||||||||||||||||
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References
- [1]. Khan R, et al. Phenolic substances of Caragana conferta and their superoxide scavenging activity. Chemistry of Natural Compounds, 2010, 46(5): 722-725.
- [2]. Shi ZH, et al. Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. Eur J Med Chem. 2015 Dec 1;106:95-105. [Content Brief]
