673-18-7
673-18-7
Chemical Structure
Norfenfluramine hydrochloride
Synonym(s): (±)-Norfenfluramine hydrochloride
- CAS No.: 673-18-7
- Formula:C10H13ClF3N
- Molecular Weight:239.67
InChIKey: PIDLOFBRTWNFAR-UHFFFAOYSA-N
SMILES: NC(CC1=CC=CC(C(F)(F)F)=C1)C.Cl
Biological Activity: Norfenfluramine hydrochloride ((±)-Norfenfluramine hydrochloride) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine hydrochloride can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine hydrochloride displays antiepileptic effects in vivo[1][2][3].
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Norfenfluramine hydrochloride | Norfenfluramine hydrochloride ((±)-Norfenfluramine hydrochloride) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine hydrochloride can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine hydrochloride displays antiepileptic effects in vivo. | |||||||||||||||||||||
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References
- [1]. Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261. [Content Brief]
- [2]. Rothman RB, Clark RD, Partilla JS, Baumann MH. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003;305(3):1191-1199. [Content Brief]
- [3]. Erenburg N, Hamed R, Shaul C, Perucca E, Bialer M. Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia. 2023;64(6):1673-1683. [Content Brief]
Keywords
