825643-56-9
Chemical Structure
RO4583298
- CAS No.: 825643-56-9
- Formula:C30H30F7N3O3
- Molecular Weight:613.57
IUPAC Name: 2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(4-fluoro-2-methylphenyl)-6-((2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
InChIKey: QOOXCQFWUYVSGU-RPBOFIJWSA-N
SMILES: O=C(N(C1=C(C2=CC=C(F)C=C2C)C=C(N3[C@H](CO)[C@@H](O)CC3)N=C1)C)C(C)(C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Biological Activity: RO4583298 is a potent, orally active dual antagonist of NK1 (human and gerbil)/NK3 (human, cynomolgus monkey, gerbil and guinea-pig). RO4583298 inhibits senktide-induced potentiation of spontaneous activity of dopaminergic neurons. RO4583298 can block gerbil foot tapping response and inhibits mouse tail whips[1].
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RO4583298 | RO4583298 is a potent, orally active dual antagonist of NK1 (human and gerbil)/NK3 (human, cynomolgus monkey, gerbil and guinea-pig). RO4583298 inhibits senktide-induced potentiation of spontaneous activity of dopaminergic neurons. RO4583298 can block gerbil foot tapping response and inhibits mouse tail whips. | |||||||||||||||||||||
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