85754-59-2
Chemical Structure
Ambamustine
Synonym(s): PTT119
- CAS No.: 85754-59-2
- Formula:C29H39Cl2FN4O4S
- Molecular Weight:629.61
IUPAC Name: ethyl ((S)-2-((S)-2-amino-3-(4-fluorophenyl)propanamido)-3-(3-(bis(2-chloroethyl)amino)phenyl)propanoyl)-L-methioninate
InChIKey: XPGDODOEEWLHOI-GSDHBNRESA-N
SMILES: CSCC[C@@H](C(OCC)=O)NC([C@H](CC1=CC=CC(N(CCCl)CCCl)=C1)NC([C@H](CC2=CC=C(F)C=C2)N)=O)=O
Biological Activity: Ambamustine (PTT119) is a bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities[1][2].
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Ambamustine | Ambamustine (PTT119) is a bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities. | |||||||||||||||||||||
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- [1]. M J Yagi, et al. Interference of mouse mammary tumor virus replication by PTT.119 [p-fluoro-L-phe-m-bis-(2-chloroethyl)amino-L-phe-met ethoxy HCl]--an antitumor agent. J Natl Cancer Inst. 1986 Mar;76(3):493-501. [Content Brief]
- [2]. A Ardizzoni, et al. Ambamustine in the second-line treatment of patients with small-cell lung cancer: a phase II Fonicap study. Am J Clin Oncol. 2000 Feb;23(1):22-5. [Content Brief]
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